Fig. 6
From: Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria
Diagram depicting the development of chronic post-sepsis skeletal muscle weakness. Sepsis induces significant inflammation that resolves early during sepsis pathogenesis. This inflammation is accompanied by acute muscle weakness that mostly resolves within two weeks and progressive muscle weakness. While mitochondrial abnormalities occur early, they accumulate as inflammation and muscle atrophy resolve, leaving altered mitochondrial function and morphology as major causes of chronic skeletal muscle weakness