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Table 3 ROC curves

From: Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus

Proteins

Healthy versus T1DM

Healthy versus MS

T1DM versus MS

AUC (95% CI)

Sensitivity (%)

Specificity (%)

p-value

AUC (95% CI)

Sensitivity (%)

Specificity (%)

p-value

AUC (95% CI)

Sensitivity (%)

Specificity (%)

p-value

TTR

0,95 (0,8573–1)

100

77,78

0,0013

0,8765 (0,6974–1)

100

77,78

0,0071

0,1975 (0–0,4228)

77,78

22,22

0,03051021

SRSF10

0,8641 (0,6819–1)

100

55,56

0,0092

0,8518 (0,6616–1)

100

55,56

0,0118

0,4074 (0,1317–0,6830)

55,56

33,33

0,50,780,065

RSP21

0,9012 (0,7535–1)

100

77,78

0,0041

0,8271 (0,6187–1)

100

77,78

0,0193

0,4567 (0,1714–0,7420)

77,78

44,44

0,75,727,775

SRP9

0,8518 (0,6758–1)

88,89

55,56

0,0118

0,9259 (0,8046–1)

77,78

77,78

0,0023

0,4938 (0,2005–0,7870)

77,78

55,56

0,96,478,398

DBI

1 (1–1)

100

100

0,0003

0,8271 (0,6237–1)

100

100

0,0193

0,2962 (0,0474–0,5451)

44,44

55,56

0,14,512,036

BTF3

0,9012 (0,7571–1)

88,89

77,78

0,0041

0,765 (0,5304–1)

88,89

77,78

0,0576

0,4691 (0,1899–0,7483)

55,56

44,44

0,8,252,829

GZMK

0,7654 (0,5417–0,9891)

77,78

66,67

0,0576

0,8395 (0,65,038–1)

77,78

66,67

0,0152

0,4444 (0,1590–0,7298)

44,44

44,44

0,69,110,222

RO60

0,9135 (0,7799–1)

100,00

77,78

0,0031

0,8518 (0,6409–1)

100

77,78

0,0118

0,6049 (0,3290–0,8808)

66,67

66,67

0,45,291,248

STMN1

0,8395 (0,6295–1)

88,89

88,89

0,0152

0,8888 (0,7392–1)

88,89

88,89

0,0054

0,679 (0,4055–0,9524)

77,78

77,78

0,20,041,107

CSTB

0,0493 (0–0,1426)

22,22

11,11

0,0013

0,2592 (0,0271–0,4913)

11,11

33,33

0,0851

0,7777 (0,5499–1)

77,78

77,78

0,04694473

LAMTOR5

0,1851 (0–0,4219)

22,22

11,11

0,0243

0,4197 (0,1211–0,71,834)

77,78

11,11

0,5660

0,6049 (0,3328–0,8770)

66,67

55,56

0,45,291,248

RASSF2

0,037 (0–0,1200)

11,11

33,33

0,0009

0,2839 (0,0268–0,5410)

11,11

33,33

0,1223

0,7654 (0,5417–0,9891)

66,67

77,78

0,05763072

GLRX

0,2098 (0–0,4344)

22,22

55,56

0,0380

0,1111 (0–0,2708)

22,22

55,56

0,0054

0,4197 (0,1428–0,6966)

44,44

55,56

0,56,599,215

ENAM

0,8395 (0,6370–1)

77,78

88,89

0,0152

0,8024 (0,5914–1)

77,78

88,89

0,0305

0,4444 (0,1608–0,7280)

44,44

55,56

0,69,110,222

CD59

0,8765 (0,7158–1)

88,89

66,67

0,0071

0,8271 (0,6370–1)

88,89

66,67

0,0193

0,395 (0,1268–0,6632)

44,44

44,44

0,45,291,248

  1. Receiver operating characteristic (ROC) analysis of proteins in T1DM and MS versus Healthy individuals and T1DM versus MS comparisons of common dysregulated proteins between groups. AUC; Area Under the curve ROC and 95% confidence intervals
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Molecular Medicine

ISSN: 1528-3658