Fig. 7
From: CYFIP1 coordinate with RNMT to induce osteosarcoma cuproptosis via AURKAIP1 m7G modification
CYFIP1 coordinated with RNMT to induce cuproptosis via AURKAIP1/FDX1 pathway. A, B. Gene set enrichment analysis and volcano map of mitochondrial proteomics. C, D. Overexpression of CYFIP1 increased the expression of AURKAIP1 and FDX1. E. Overexpression of CYFIP1 decreased the mitochondrial membrane potential in osteosarcoma cells. F. Overexpression of CYFIP1 elevated the ROS level in osteosarcoma cells. G. Overexpression of CYFIP1 destroyed the structure of mitochondrion. H. The overexpression of CYFIP1 could induce the aggregation of DLAT