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Fig. 2 | Molecular Medicine

Fig. 2

From: USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer

Fig. 2

USP14 promotes CRC (MSI-H) tumorigenesis and oxaliplatin resistance. CCK8 detects cell proliferation activity a. Image and quantitative analysis of cell cloning and formation b. The EdU staining results and quantification of different groups c. The apoptotic cells were measured by flow cytometry and analyzed by flow Jo d. The apoptosis-associated markers were evaluated by Western blot e. Measurement of the role of USP14 knockdown on the subcutaneous xenograft tumors from LoVo cells f, tumor volume g and tumor weight h were shown. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are presented as the mean ± SD of three separate experiments

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Molecular Medicine

ISSN: 1528-3658