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Fig. 7 | Molecular Medicine

Fig. 7

From: BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NAD+ transport in intrahepatic cholestasis of pregnancy

Fig. 7

Suppression of SLC25 A51 expression reversed effect of silencing BACH1 on proliferation of HUVECs stimulated by TCA. A Western blotting of VEGFR2, CD146, CD34, CD35, vWF, VEGFA, and PCNA in siNC, shNC, siBACH1, and shSLC25 A51 HUVECs treated with TCA for 24 h (n = 3). B, C Relative EdU+ cells in siNC, shNC, siBACH1, and shSLC25 A51 HUVECs treated with TCA for 24 h (n = 3). D, E Wound healing assay of siNC, shNC, siBACH1, and shSLC25 A51 HUVECs treated with TCA for 24 h (n = 3). F Different colors represent corresponding groups. One-way analysis of variance (ANOVA) followed by Tukey’s post-hoc analysis; ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001

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