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Fig. 1 | Molecular Medicine

Fig. 1

From: STMN1–IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights

Fig. 1

Increased STMN1 expression in human degenerative NP tissues. A MRI T2-weighted sagittal images of the spine in low-grade IDD (LIDD) and high-grade IDD (HIDD) groups under the Pfirrmann grading method. B Histological staining of NP tissue using HE, Safranin O, Alcian Blue, and Masson. C Immunohistochemistry showing markers of cellular senescence (p16 and p21), ECM metabolism (MMP3 and Collagen II), and STMN1 in LIDD and HIDD groups (n = 3). D Western blot showing protein expression of p16, p21, MMP3, ADAMTS4, Aggrecan, Collagen II, and STMN1 in NP tissues of LIDD and HIDD groups (n = 9). E–K Statistical analysis of western blot data. L–P Statistical analysis of immunohistochemical data. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658