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Table 3 Checkerboard assays between erythromycin and the cpl-1 endolysin with the erythromycin-resistant pneumococcal isolates. The table indicates minimal inhibitory concentrations observed for erythromycin, endolysin cpl-1 or the different combinations thereof. FIC is the fractional inhibitory concentration, which indicates additive effects if values are between 0.50 and 4.00. The EUCAST breakpoint for erythromycin resistance is set at 0.25 µg/mL

From: Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections

 

AMR 6 A

AMR 12,116

AMR 68,715

Cpl-1

20.00 µM

5.00 µM

0.31 µM

Erythromycin

4.00 µg/mL

0.50 µg/mL

0.50 µg/mL

Erythromycin + cpl-1

0.50 µg/mL

0.06 µg/mL

0.01 µg/mL

Cpl-1 + erythromycin

20.00 µM

5.00 µM

0.31 µM

FIC

1.125

1.125

1.032