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Fig. 7 | Molecular Medicine

Fig. 7

From: JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction

Fig. 7

JAK and STAT3 inhibitors attenuated the JAK2/STAT3/HMGCS2 signaling pathway in the hearts of hyperuricemic mice. A and C Representative immunohistochemical images of IL-6 (brown) in mouse heart tissues (scale bar: 100 µm) (A) and the corresponding statistical analysis (C) (n = 5 mice/group). B Representative western blot images of P-JAK2, T-JAK2, P-STAT3, T-STAT, and HMGCS2 protein levels. D-H Quantitative statistical diagrams of P-JAK2 (D), T-JAK2 (E), P-STAT3 (F), T-STAT (G), and HMGCS2 (H) detected by western blot (n = 5 mice/group). The data represent the means ± S.E.M.s. *p < 0.05 vs the control group. #p < 0.05 vs the hyperuricemia group

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Molecular Medicine

ISSN: 1528-3658