Fig. 3

Gliomas clustering based on m6 A profile. A Hierarchical clustering dendrogram of the glioma m6 A modified lncRNA profile dataset, using adenine methylation status data from 14 lncRNA RRACHs. Glioma samples are grouped into C1and C2 clusters based on the similarity of m6 A pattern. B Heat-map of m6 A methylation profiles of RRACH motifs in 14 selected lncRNAs m6 A hits across different clusters. Red indicates methylated adenine (mod), light gray indicates unmethylated adenine (unmod), and dark gray indicates an unidentified adenine state within the RRACH motif. Tumor location of each case is shown on a color as follows: blue – Cerebellum, red – Frontal lobe, Green – Frontotemporal, orange – Occipital lobe, yellow – Parietal lobe, purple – Temporal lobe. C Principal component analysis (PCA) plot of glioma cases, displaying the first two components (explaining 64.6% of variance) generated using the 14 most informative RRACH motifs