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  1. Evobrutinib, a third-generation Bruton's tyrosine kinase (BTK) inhibitor, shows great promise for treating neuroinflammatory diseases due to its small molecular size, ease of absorption, and ability to cross t...

    Authors: Yixiang Jiang, Ning Wang, Jingyi Liu, Jiayi Li, Lulu Chang, Changxin Yang, Zhengyi Chen, Wei Huang, Jing Wang, Xiujuan Lang, Xijun Liu, Yumei Liu, Bo Sun and Hulun Li
    Citation: Molecular Medicine 2025 31:148
    Content type: Research Published on:

  2. In the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is e...

    Authors: Wenjie Zhang, Min Xia, Jiahui Li, Gaohua Liu, Yan Sun, Xisha Chen and Jing Zhong
    Citation: Molecular Medicine 2025 31:146
    Content type: Review Published on:

  3. Alcohol-associated liver disease (ALD) with steatosis or steatohepatitis that could progress to liver cirrhosis is a common problem in chronic alcohol consumption. Pemafibrate is a novel, highly specific perox...

    Authors: Takashi Saito, Joseph George, Kazuaki Ozaki, Mutsumi Tsuchishima and Mikihiro Tsutsumi
    Citation: Molecular Medicine 2025 31:145
    Content type: Research Published on:

  4. Aortic dissection (AD) patients with malperfusion present significant challenges and are associated with high postoperative mortality rates. Limited data exist regarding the management of patients with AD and ...

    Authors: Qiwen Tan, Xiaokang Wang, Wanchuang Xu, Kun Song, Yifan Xiong, Zhentong Jiang, Jingjing Li, Yunsheng Yu, Wenxue Ye, Zhenya Shen and Xiaomei Teng
    Citation: Molecular Medicine 2025 31:144
    Content type: Research Published on:

  5. Ovarian cancer (OC) is a highly aggressive malignancy characterized by early dissemination of cancer cells from the surface of the ovary to the peritoneum. To gain a deeper understanding of the mechanisms asso...

    Authors: Francesca Gorini, Camelia Alexandra Coada, Sarah Monesmith, Antonio De Leo, Dario de Biase, Giulia Dondi, Stella Di Costanzo, Francesco Mezzapesa, Ivan Vannini, Mattia Melloni, Sara Bandini, Flora Guerra, Riccardo Di Corato, Pierandrea De Iaco, Patrizia Hrelia, Anna Myriam Perrone…
    Citation: Molecular Medicine 2025 31:143
    Content type: Research Published on:

  6. The regulatory molecule Human Leukocyte Antigen F (HLA-F) has been implicated in trophoblast proliferation during pregnancy, and reduced levels of this antigen have been identified in trophoblast cells of pati...

    Authors: Ruiling Xu, Yu Huang, Wenchi Xie, Dan Luo, Jie Mei, Xinghui Liu, Fulin Liu and Fangyuan Luo
    Citation: Molecular Medicine 2025 31:142
    Content type: Research Published on:

  7. Tripartite motif-containing 27 (TRIM27) is highly expressed in the mouse thymus, spleen, and hematopoietic compartment cells and regulates cell proliferation, apoptosis, and innate immune responses. However, t...

    Authors: Kabsun Kim, Jung Ha Kim, Inyoung Kim, Semun Seong, Hyun Kook, Jeong-Tae Koh and Nacksung Kim
    Citation: Molecular Medicine 2025 31:141
    Content type: Research Published on:

  8. The limited genomic data on non-muscle-invasive bladder cancer (NMIBC) hampers our understanding of its carcinogenesis and development. Specifically, Aristolochic acid (AA), a potent human carcinogenic compoun...

    Authors: Yun Peng, Yuxuan Song, Caipeng Qin, Mengting Ding, Zixiong Huang, Fei Wang, Yuchao HuangFu, Luping Yu, Yiqing Du and Tao Xu
    Citation: Molecular Medicine 2025 31:140
    Content type: Research Published on:

  9. Severe ionizing radiation (IR) causes the acute lethal damage of hematopoietic system and gastrointestinal tract. By establishing a radiation injury model, we found that Diprovocim, a TLR2 agonist, protected m...

    Authors: Duo Fang, Hainan Zhao, Lu Pei, Kai Jiang, Yuhan Gan, Xuanlu Zhai, Liao Zhang, Ying Cheng, Cong Liu, Jicong Du and Fu Gao
    Citation: Molecular Medicine 2025 31:139
    Content type: Research Published on:

  10. Abdominal aortic aneurysm (AAA) is a common degenerative disease of the abdominal aorta, which can result in extremely high mortality owing to the rupture of the abdominal aorta. The activation of IL-7R has be...

    Authors: Shengnan Xu, Xueyu Han, Yi Yu, Chuan Qu, Bo Yang, Bo Shen and Xin Liu
    Citation: Molecular Medicine 2025 31:138
    Content type: Research Published on:

  11. Authors: Zhixuan Wu, Haoyi Xiang, Xiaowu Wang, Rongrong Zhang, Yangyang Guo, Liangchen Qu, Jingyao Zhou and Yanyi Xiao
    Citation: Molecular Medicine 2025 31:137
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2024 30:166

  12. Tissue acidosis is a key characteristic of RA. It remains unclear whether acidosis promotes the formation of the complex adaptive immune landscape mainly characterized by T cell activation in RA by influencing...

    Authors: Xuewen Qian, Zhuoyan Zai, Yuemin Tao, Huifang Lv, Mengjia Hao, Longbiao Zhang, Xiaoyue Zhang, Yayun Xu, Yihao Zhang and Feihu Chen
    Citation: Molecular Medicine 2025 31:136
    Content type: Research Published on:

  13. Huntington’s disease (HD) is a rare dominantly inheritable autosomal neurodegenerative disease with unclear pathophysiological pathways. In neurodegenerative disorders, including HD, necroptosis plays a signif...

    Authors: Eman M. Elbaz, Rabab H. Sayed, Amany A. Abdelkader and Atef Tadros Fahim
    Citation: Molecular Medicine 2025 31:135
    Content type: Research Published on:

  14. Endometriosis, a common condition affecting 5–10% of women of reproductive age, is the growth of endometrial-like tissue outside the uterus, leading to pain and infertility. Current treatments, such as surgery...

    Authors: Martina Placidi, Giovanni Casoli, Teresa Vergara, Andrea Bianchi, Domenica Cocciolone, Silvia Zaccardi, Guido Macchiarelli, Maria Grazia Palmerini, Carla Tatone, Arturo Bevilacqua and Giovanna Di Emidio
    Citation: Molecular Medicine 2025 31:134
    Content type: Research Published on:

  17. Osteoporosis (OP) is a common systemic metabolic bone disease characterized by the decrease in bone mass and hyperactivity of osteoclasts. ACT001 is approved as an orphan drug by FDA and has shown multiple pro...

    Authors: Yuan Li, Jin-Yu Yang, Ma-Li Lin, Tian-Zhu Liu, Wen-Na Lu, Ying Yang, Zhong-Cheng Liu, Jian-Heng Li, Guo-Qiang Zhang and Jian-Shuang Guo
    Citation: Molecular Medicine 2025 31:131
    Content type: Research Published on:

  18. Cancer-induced bone pain (CIBP) is a complex chronic pain with poorly understood mechanisms. The anterior cingulate cortex (ACC) plays a critical role in processing and modulating chronic pain. This study inve...

    Authors: Futing Ba, Jinrong Wei, Qi-Yan Feng, Chen-Yang Yu, Meng-Xue Song, Shufen Hu, Guang-Yin Xu, Hai-Long Zhang and Guo-Qin Jiang
    Citation: Molecular Medicine 2025 31:130
    Content type: Research Published on:

  20. Temporomandibular joint osteoarthritis (TMJ-OA) is a disease characterized by cartilage degradation and synovial inflammation, with limited effective treatment currently. Synovial macrophage polarization is pi...

    Authors: Wenyi Cai, Antong Wu, Zhongxiao Lin, Wei Cao, Janak L. Pathak, Richard T. Jaspers, Rui Li, Xin Li, Kaihan Zheng, Yufu Lin, Na Zhou, Xin Zhang, Yizhun Zhu and Qingbin Zhang
    Citation: Molecular Medicine 2025 31:128
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Medicine 2025 31:156

  22. Pancreatic cancer (PC) has high lethality due to multiple reasons, and its limited response to conventional chemotherapy like gemcitabine (GEM) is a non-negligible one. Therefore, our study introduces Chloroph...

    Authors: Jiaqiang Ren, Tong Su, Jiachun Ding, Fan Chen, Jiantao Mo, Jie Li, Zheng Wang, Liang Han, Zheng Wu and Shuai Wu
    Citation: Molecular Medicine 2025 31:126
    Content type: Research Published on:

  23. Riboflavin kinase (RFK, also called flavokinase) is a catalytic enzyme that converts riboflavin to its active form in vivo. Dysfunction of the RFK gene has been associated with susceptibility to ischemic strok...

    Authors: Yingxin Zou, Minghua Ruan, Xu Feng, Fei Liu, Weihong Liu, Song Chen and Zhiyong Chu
    Citation: Molecular Medicine 2025 31:125
    Content type: Research Published on:

  24. Colon anastomotic leakage (CAL) is a postoperative complication originating from disturbed colon anastomotic healing (CAH). Wound healing involves several well-coordinated stages, which have not been comprehen...

    Authors: Hilal Sengul, Vasiliki Bantavi, Laura Gloeck, Andrew Y. F. Li Yim, Patrick Leven, Patrik Efferz, Bianca Schneiker, Mariola Lysson, Wouter J. De Jonge and Sven Wehner
    Citation: Molecular Medicine 2025 31:124
    Content type: Research article Published on:

  25. Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinica...

    Authors: Quanpeng Qiu, Yi Ding, Xiaolong Guo, Jing Han, Jiaqi Zhang, Yaping Liu, Junjun She and Yinnan Chen
    Citation: Molecular Medicine 2025 31:123
    Content type: Research Published on:

  26. Osteoporosis, resulting from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation, affects millions globally. Recent studies have identified type H vessels (CD31hiEMCNhi

    Authors: Hao Yin, Zhe Ruan, Teng-Fei Wan, Zhi-Rou Lin, Chun-Yuan Chen, Zhen-Xing Wang, Jia Cao, Yi-Yi Wang, Ling Jin, Yi-Wei Liu, Guo-Qiang Zhu, Jiang-Shan Gong, Jing-Tao Zou, Yi Luo, Yin Hu, Zhao-Hui Li…
    Citation: Molecular Medicine 2025 31:122
    Content type: Research Published on:

  27. Aberrant mRNA splicing is a well-established pathogenic mechanism for human disease, but its real impact is hardly predictable and underestimated. Splicing can be therefore modulated for therapeutic purposes, ...

    Authors: Laura Peretto, Claudia D’angiolillo, Paolo Ferraresi, Dario Balestra and Mirko Pinotti
    Citation: Molecular Medicine 2025 31:121
    Content type: Brief Report Published on:

  28. Abdominal aortic aneurysm (AAA) is an inflammation-driven disease in which neutrophil infiltration is critical to its progression. This study aims to explore the molecular mechanisms behind neutrophil infiltra...

    Authors: Bohan Yang, Yiyan Xu, Fengfei Yan, Cheng Peng, Ye Song, Song Han and Haiyang Wang
    Citation: Molecular Medicine 2025 31:120
    Content type: Research Published on:

  29. C-terminal binding protein-2 (Ctbp2) is an evolutionarily conserved transcriptional repressor that regulates fundamental processes such as cell proliferation and apoptosis. However, the potential role of Ctbp2...

    Authors: Yanting Meng, Jianwen Ding, Yanping Wang, Jing Wang, Wei Huang, Wenkang Jiang, Jiayi Li, Xiujuan Lang, Sifan Zhang, Yumei Liu, Xijun Liu, Hulun Li and Bo Sun
    Citation: Molecular Medicine 2025 31:119
    Content type: Research Published on:

  30. Ossification of the ligamentum flavum (OLF) is characterized by ligamentum flavum thickening and subsequent thoracic canal stenosis. Emerging evidence has demonstrated the involvement of N6-methyladenosine (m6...

    Authors: Jiaming Zhou, Rui Wang, Zequn Zhang and Yuan Xue
    Citation: Molecular Medicine 2025 31:118
    Content type: Research Published on:

  31. Fluoride exposure during pregnancy commonly compromises fetal neurodevelopment and largely results in a broad spectrum of cognitive deficiencies in the adult offspring. However, the precise mechanisms underlyi...

    Authors: Yongle Cai, Xingdong Zeng, Mengyan Wu, Haonan Chen, Miao Sun and Hao Yang
    Citation: Molecular Medicine 2025 31:117
    Content type: Research Published on:

  32. The anti-HER2 monoclonal antibody trastuzumab and new derivative formulations are the standard treatment for HER2-positive breast cancer. However, after 1 to 5 years of treatment, some patients acquire resista...

    Authors: Ana Lameirinhas, Sandra Torres-Ruiz, Iris Garrido-Cano, Cristina Hernando, María Teresa Martínez, Ana Rovira, Joan Albanell, Sandra Zazo, Federico Rojo, Begoña Bermejo, Ana Lluch, Juan Miguel Cejalvo, Eduardo Tormo and Pilar Eroles
    Citation: Molecular Medicine 2025 31:116
    Content type: Research Published on:

  33. Chemotherapy resistance is a major challenge in the treatment of intermediate and advanced gastric cancer (GC). This study aimed to recognize oxaliplatin resistance-related genes (OXARGs) in GC and to explore ...

    Authors: Yan Zhang, Jian Cao, Zheng Yuan, Jiahui Zhou, Hao Zuo, Xinsheng Miao and Xinhua Gu
    Citation: Molecular Medicine 2025 31:115
    Content type: Research Published on:

  34. Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by accelerated aging, impaired growth, disrupted lipid metabolism, and reduced lifespan.

    Authors: Jingjing Wang, Yuelin Guan, Yue Wang, Junyi Tan, Zhongkai Cao, Yuhan Ding, Langping Gao, Haidong Fu, Xiangjun Chen, Jianyu Lin, Ning Shen, Xudong Fu, Fangqin Wang, Jianhua Mao and Lidan Hu
    Citation: Molecular Medicine 2025 31:114
    Content type: Research Published on:

  35. Retinopathy of prematurity (ROP) is a disorder that causes blindness in children at a high incidence. Retinal endothelial cells are damaged by variations in oxygen partial pressure, which leads to vascular obs...

    Authors: Rui Niu, Jing Wang, Xiaolin Pan, Min Ran, Peng Hao, Wei Zhang, Yatu Guo and Wei Zhang
    Citation: Molecular Medicine 2025 31:113
    Content type: Research article Published on:

  36. Ischemic stroke is characterized by high mortality and high disability rates and accounts for the vast majority of current stroke cases. Reperfusion after surgical treatment can cause serious secondary damage ...

    Authors: Yuchun Wang, Yang Yang, Tuo Meng, Shengwei Liu, Jingdong Liu, Daohang Liu, Bharati Laxman, Sha Chen and Zhi Dong
    Citation: Molecular Medicine 2025 31:112
    Content type: Research Published on:

  37. The enlarged vestibular aqueduct (EVA) is the most commonly detected inner ear malformation. Biallelic pathogenic variants in the SLC26A4 gene, coding for the anion exchanger pendrin, are frequently involved in d...

    Authors: Emanuele Bernardinelli, Raffaella Liuni, Rapolas Jamontas, Paola Tesolin, Anna Morgan, Giorgia Girotto, Sebastian Roesch and Silvia Dossena
    Citation: Molecular Medicine 2025 31:111
    Content type: Research Published on:

  38. The states of Schwann cells undergo significant shifts during nerve regeneration. Previous studies have shown the expression of Runx2 is locally upregulated within the affected areas. However, the regulatory m...

    Authors: Bo He, Shouwen Su, Zeyu Zhang, Zhongpei Lin, Qinglin Qiu, Yan Yang, Xiaoyue Wen and Zhaowei Zhu
    Citation: Molecular Medicine 2025 31:110
    Content type: Research Published on:

  39. Cyanotic congenital heart disease (CHD) in children has been associated with neurodevelopmental abnormalities, although the underlying mechanisms remain largely unknown. Multiple factors are likely involved in...

    Authors: Renwei Chen, Haifan Wang, Liqin Zeng, Jiafei He, Xiaohan Liu, Xinting Ji, Paul Yao and Shuo Gu
    Citation: Molecular Medicine 2025 31:109
    Content type: Research Published on:

  40. Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration and neuropsychiatric abnormalities. Loss of full-length dystrophins is both necessary and sufficient to initiate DMD. These...

    Authors: Joanna Pomeroy, Malgorzata Borczyk, Maria Kawalec, Jacek Hajto, Emma Carlson, Samuel Svärd, Suraj Verma, Eric Bareke, Anna Boratyńska-Jasińska, Dorota Dymkowska, Alvaro Mellado-Ibáñez, David Laight, Krzysztof Zabłocki, Annalisa Occhipinti, Loydie Majewska, Claudio Angione…
    Citation: Molecular Medicine 2025 31:108
    Content type: Research Published on:

  41. The human body is highly dependent on adequate oxygenation of the cellular space for physiologic homeostasis mediation. The insufficient oxygenation of the cellular space leads to hypoxia. Hypobaric hypoxia (H...

    Authors: Prosperl Ivette Wowui, Richard Mprah, Marie Louise Ndzie Noah, Joseph Adu-Amankwaah, Anastasia Wemaaatu Lamawura Kanoseh, Li Tao, Diana Chulu, Simon Kumah Yalley, Saffia Shaheen and Hong Sun
    Citation: Molecular Medicine 2025 31:107
    Content type: Research Published on:

  43. Epitranscriptomics, the study of RNA modifications such as N6-methyladenosine (m6A), provides a novel layer of gene expression regulation with implications for numerous biological processes, including cellular ad...

    Authors: Daniel Benak, Petra Alanova, Kristyna Holzerova, Miloslava Chalupova, Barbora Opletalova, Frantisek Kolar, Gabriela Pavlinkova and Marketa Hlavackova
    Citation: Molecular Medicine 2025 31:105
    Content type: Review Published on:

  44. Accumulative evidence has shown that systemic lupus erythematosus (SLE) increases the risk of various cardiovascular diseases including atrial fibrillation (AF). The study aimed to screen potential key genes u...

    Authors: Hongjie Xu, Sufan Ding, Xiaoping Ning, Ye Ma, Qi Yu, Yi Shen, Lin Han and Zhiyun Xu
    Citation: Molecular Medicine 2025 31:104
    Content type: Research article Published on:

  46. MicroRNAs (miRNAs) are gene regulators essential for cell homeostasis, their alteration is related to a pathological state, including infectious diseases like COVID-19. Identifying an altered profile of circul...

    Authors: Malena Gajate-Arenas, Candela Sirvent-Blanco, Omar García-Pérez, Angélica Domínguez-de-Barros, José E. Piñero, Jacob Lorenzo-Morales and Elizabeth Córdoba-Lanús
    Citation: Molecular Medicine 2025 31:102
    Content type: Research Published on:

  47. Epimedium brevicornum Maxim (EP) has a history of utilization in Chinese traditional medicine for the treatment of bone diseases. However, the precise mechanism by which EP extract (EPE) operates in Diabetes oste...

    Authors: Shan Shan Lei, Yu Yan Wang, Xiao Wen Huang, Xu Ping Wang, Ming Gao and Bo Li
    Citation: Molecular Medicine 2025 31:101
    Content type: Research Published on:

  48. Acute myocardial infarction (AMI) is a leading cause of mortality, characterized by myocardial ischemia that induces cardiomyocyte apoptosis and subsequent cardiac dysfunction. Sirtuin 1 (Sirt1) has emerged as...

    Authors: Yafen Chen, Shuyao Shan, Qiqi Xue, Yan Ren, Qihong Wu, Jiawei Chen, Ke Yang and Jiumei Cao
    Citation: Molecular Medicine 2025 31:100
    Content type: Research Published on:

  49. Liver X receptor α (LXRα) plays an important role in inflammatory immune response induced by hepatic ischemia-reperfusion injury (IRI) and acute rejection (AR). Macrophage M1-polarization play an important rol...

    Authors: Xiaoyan Qin, Dingheng Hu, Qi Li, Shiyi Zhang, Zheng Qin, Liangxu Wang, Rui Liao, Zhongjun Wu and Yanyao Liu
    Citation: Molecular Medicine 2025 31:99
    Content type: Research Published on:

  50. Meteorin-like hormone (Metrnl) is prominently expressed in activated M2 macrophages and has demonstrated potential therapeutic effects in a range of cardiovascular diseases by modulating inflammatory responses...

    Authors: De-Xin Chen, Yang-Yi Feng, Hai-Yan Wang, Chuang-Hong Lu, De-Zhao Liu, Chen Gong, Yan Xue, Na Na and Feng Huang
    Citation: Molecular Medicine 2025 31:98
    Content type: Research Published on:
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    Journal Impact Factor: 6.0
    5-year Journal Impact Factor: 6.0
    Source Normalized Impact per Paper (SNIP): 0.907
    SCImago Journal Rank (SJR): 1.446

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    Submission to first editorial decision (median days): 3
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Molecular Medicine

ISSN: 1528-3658