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  2. Efforts to understand the interplay between m6A (N6-methyladenosine) modification and long non-coding RNAs (lncRNAs) in the pathogenesis of various diseases, including cancer, have recently attracted considera...

    Authors: Giedrius Steponaitis, Rugile Dragunaite, Rytis Stakaitis, Amit Sharma, Arimantas Tamasauskas and Daina Skiriute
    Citation: Molecular Medicine 2025 31:195
    Content type: Research Published on:

  3. Bone fragility due to poor glycemic control is a recognized complication of diabetes, but the mechanisms underlying diabetic bone disease remain poorly understood. Despite the importance of bioenergetics in ti...

    Authors: Rita Araújo, Raquel L. Bernardino, Mariana P. Monteiro and Pedro S. Gomes
    Citation: Molecular Medicine 2025 31:194
    Content type: Research Published on:

  5. Acute kidney injury (AKI) is a serious clinical condition characterized by a rapid decline in renal function, often progressing to chronic kidney disease (CKD) and fibrosis. The endogenous mechanisms influenci...

    Authors: Elisa Perez-Moreno, Adely de la Peña, Tomás Toledo, Javiera Saez, Francisca Pérez-Molina, Sofía Espinoza, Claudia Metz, Nicole Díaz-Valdivia, Lorena Azócar, Carolina Prado, Rodrigo Pacheco, Fabian Segovia-Miranda, Alejandro S. Godoy, Cristian A. Amador, Teo Feuerhake, Alfonso González…
    Citation: Molecular Medicine 2025 31:192
    Content type: Research Published on:

  6. Diacylglycerol O-acyltransferase 1 (DGAT1) is crucial for triglyceride synthesis, yet its role in ischemic stroke remains unclear. This study investigated DGAT1 in ischemic stroke using middle cerebral artery ...

    Authors: Youjie Zeng, Ren Guo, Songhua Chen, Yuxin Lin, Si Cao, Xia Wang, Siyi Zhang, Huilin Xu, Wenxiang Qing, Heng Yang and Wen Ouyang
    Citation: Molecular Medicine 2025 31:191
    Content type: Research Published on:

  8. The causal relationship between the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and the preservation of SERCA2a function in mitigating myocardial ischemia–reperfusion (mI/R) injury, along ...

    Authors: Maria del Carmen Asensio-Lopez, Miriam Ruiz-Ballester, Silvia Pascual-Oliver, Francisco Jose Bastida-Nicolas, Yassine Sassi, Jose Javier Fuster, Domingo Pascual-Figal, Fernando Soler and Antonio Lax
    Citation: Molecular Medicine 2025 31:189
    Content type: Research Published on:

  9. The activation of brown adipose tissue (BAT) or the browning of white adipose tissue (WAT) represents a promising therapeutic strategy for obesity. Arctiin (ARC), a lignan compound known for its anti-inflammat...

    Authors: Yuanfeng Gu, Wenjun He, Wenxuan Li, Jingshu Cai, Zhuyun Wang, Kemeng Li, Guangcheng Qin, Xiaojie Gu, Xiaojing Lin, Li Ma, Xiaoqiu Xiao, Yi Hou and Ting Luo
    Citation: Molecular Medicine 2025 31:188
    Content type: Research Published on:

  10. GPR84 is a Gi-coupled G-protein-coupled receptor (GPCR) predominantly expressed in immune cells, with its expression upregulated during inflammatory conditions. However, its specific role in immune-mediated li...

    Authors: Yanan Zheng, Yumeng Wang, Yujie Xu, Shanshan Shen, Haozhe Xu, Chao Hu, Yongzhen Chen, Fengmeng Teng, Jinshun Pan, Shuqian Zheng, Junqi Wang, Zhongping Su and Qiang You
    Citation: Molecular Medicine 2025 31:187
    Content type: Research Published on:

  11. Vitiligo is an acquired skin depigmentation disorder often accompanied by leukoderma and leukotrichia. Half of vitiligo patients experience episodes of stress.

    Authors: Xuechen Cao, Yongkai Yu, Hang Yao, Yujie Zheng, Jiawei Lu, Yifei Feng, Tongxin Pei, Ziyu Li, Ming Lu and Yan Lu
    Citation: Molecular Medicine 2025 31:186
    Content type: Research Published on:

  12. Hypomethylating agents (HMAs), such as 5-azacytidine (AZA), are valuable treatment options for patients with acute myeloid leukemia (AML). Despite providing significant extensions in survival when used alone o...

    Authors: Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian and Edwin R. Manuel
    Citation: Molecular Medicine 2025 31:185
    Content type: Research Published on:

  13. High uric acid levels play a critical role in cardiovascular disease pathophysiology, being closely linked to their occurrence, progression, and prognosis. To enhance prevention and treatment of hyperuricemia-...

    Authors: Dewei Peng, Xiaoli He, Bowen Ren, Qian Wang, Lulu Peng, Yue Jiang, Shengqi Huo, Lintong Men, Wei Shi, Pengcheng Luo, Mengyin Zhu, Cuntai Zhang, Jiagao Lv, Li Lin and Sheng Li
    Citation: Molecular Medicine 2025 31:184
    Content type: Research Published on:

  14. Many studies have shown that pathological cardiac hypertrophy is associated with active endoplasmic reticulum (ER) stress. Glutamine-rich protein 1 (QRICH1), as a transcriptional regulator, belongs to the casp...

    Authors: Lihui Zhang, Hongping Chen, Guangmei Zou, Wenjuan Jia, Haibin Dong, Chunxiao Wang, Hua Wang, Yugang Liu, Da Teng, Bowen Xu, Lin Zhong, Lei Gong and Jun Yang
    Citation: Molecular Medicine 2025 31:183
    Content type: Research Published on:

  16. Pathogenic variants in OTOF are a major cause of auditory synaptopathy. However, challenges remain in interpreting OTOF variants, including difficulties in confirming haplotype phasing using traditional short-rea...

    Authors: Pei-Hsuan Lin, Cheng-Yu Tsai, Yu-Ting Chiang, Chang-Han Ho, Yue-Sheng Lu, Jacob Shu-Jui Hsu, Yen-Fu Cheng, Shih-Feng Tsai, Chuan-Jen Hsu, Pei-Lung Chen and Chen-Chi Wu
    Citation: Molecular Medicine 2025 31:181
    Content type: Research Published on:

  18. The remodeling of the extracellular matrix (ECM) plays a pivotal role in tumor progression and drug resistance. However, the compositional patterns of ECM in breast cancer and their underlying biological funct...

    Authors: Hongwei Wang, Yu-nan Zhu, Sifan Zhang, Kexin Liu, Rong Huang, Zhigao Li, Lan Mei and Yingpu Li
    Citation: Molecular Medicine 2025 31:179
    Content type: Research Published on:

  19. The immune system of patients undergoing major surgery usually has obvious immune responses during the perioperative period, and the patient’s immune status would affect the patient’s prognosis. In this study ...

    Authors: Yang-Yang Wang, Rui-Lou Zhu, En-Qiang Chang, Xiao-Zhuan Liu, Guang-Zhi Wang, Ning-Tao Li, Wei Zhang, Jun Zhou, Ming-Yang Sun, Xin Zou, Jie Hao and Jia-Qiang Zhang
    Citation: Molecular Medicine 2025 31:178
    Content type: Research Published on:

  20. Bone loss in Staphylococcus aureus (S. aureus) osteomyelitis poses a serious challenge to orthopedic treatment, but the underlying mechanism of systemic osteoporosis caused by chronic infection is not completely ...

    Authors: Yuhui Chen, Chao Li, Jishan Jia, Yuhui Jiang, Ping Zhang, Caiyu Cheng, Guangyan Zhang, Lang Gao, Xiang Yang, Jiawei Zhao, Kaiqun Li and Bin Yu
    Citation: Molecular Medicine 2025 31:177
    Content type: Research Published on:

  21. Sepsis is a life-threatening condition that often leads to severe complications, including acute lung injury (ALI), which carries high morbidity and mortality in critically ill patients. Melatonin (Mel) has sh...

    Authors: Yuce Peng, Jia Xu, Lingyu Wei, Minghao Luo, Shenglong Chen, Xuebiao Wei, Suxin Luo, Zedazhong Su and Zhonghua Wang
    Citation: Molecular Medicine 2025 31:176
    Content type: Research Published on:

  22. Immune checkpoint inhibitor (ICI) have shown promising results against a variety of solid tumors across clinical trials. However, ICI monotherapy is often ineffective in patients with non-immunogenic tumors th...

    Authors: Hyo Min Ahn, Bo-Kyeong Jung, JinWoo Hong, Dayoung Hong, A-Rum Yoon and Chae-Ok Yun
    Citation: Molecular Medicine 2025 31:175
    Content type: Research Published on:

  23. Immune-mediated hearing loss (IMHL) patients (comprised of autoimmune inner ear disease (AIED) and sudden sensorineural hearing loss (SSNHL)) may be at higher risk for hearing loss following Coronavirus diseas...

    Authors: Shresh Pathak, Natalie Tan and Andrea Vambutas
    Citation: Molecular Medicine 2025 31:174
    Content type: Research Published on:

  25. Spinal cord injury (SCI) is a disability that causes severe traumatic damage to the central nervous system, with increasing prevalence worldwide. Paclitaxel (PTX) is a naturally occurring plant metabolite that...

    Authors: Zhifeng Chen, Da Wo, Celiang Wu, En Ma, Jinhui Peng, Weidong Zhu and Dan-ni Ren
    Citation: Molecular Medicine 2025 31:172
    Content type: Research Published on:

  26. TREM2 encodes a microglial membrane receptor involved in the disease-associated microglia (DAM) phenotype whose activation requires the transmembrane interaction with TYROBP. Mutations in TREM2 represent a high-i...

    Authors: M. Cobas-Carreño, A. Esteban-Martos, L. Tomas-Gallardo, I. Iribarren, L. Gonzalez-Palma, A. Rivera-Ramos, J. Elena-Guerra, E. Alarcon-Martin, R. Ruiz, M. J. Bravo, J. L. Venero, X. Morató, A. Ruiz and J. L. Royo
    Citation: Molecular Medicine 2025 31:171
    Content type: Research Published on:

  27. Streptococcus pneumoniae, the pneumococcus, is a cause of major illness globally. Invasive pneumococcal disease (IPD) is characterized by pneumococci invading blood (bacteremia), lungs (pneumonia), or brain and c...

    Authors: Niels Vander Elst, Kristine Farmen, Lisa Knörr, Lotte Merlijn and Federico Iovino
    Citation: Molecular Medicine 2025 31:170
    Content type: Research Published on:

  28. Cardiovascular diseases (CVDs) represent a profound challenge with inflammation playing a significant role in their pathophysiology. Extracellular vesicles (EVs), which are membranous structures encapsulated b...

    Authors: Mengyang Wang, Yuwu Chen, Biyi Xu, Xinxin Zhu, Junke Mou, Jiani Xie, Ziao Che, Liyang Zuo, Ji Li, Haibo Jia and Bo Yu
    Citation: Molecular Medicine 2025 31:169
    Content type: Review Published on:

  29. Inflammation is a principal cause of sensorineural hearing loss resulting from cochlear injury. However, current research investigating the mechanisms of sensorineural inflammatory injury remains inadequate.

    Authors: Jintao Lou, Fan Wu, Wei Liu, Rui Hu, Wuhui He, Yisi Feng, Yan Huang, Jia Guo, Jingman Deng, Zhen Zhao, Zhigang Zhang and Yu Si
    Citation: Molecular Medicine 2025 31:168
    Content type: Research Published on:

  30. Cellular dysfunction induced by senescent nucleus pulposus (NP) cells is a key factor in the pathogenesis of intervertebral disc degeneration (IDD). Stathmin 1 (STMN1) has been proposed as a telomere-associate...

    Authors: Lei Li, Guangzhi Zhang, Zhili Yang, Zhenyu Cao, Dongxin Wang and Xuewen Kang
    Citation: Molecular Medicine 2025 31:167
    Content type: Research Published on:

  31. Nephronophthisis (NPH) is classified under the category of renal ciliopathies and is the most common genetic disease leading to renal failure in children. Early-onset and progressive renal tubulointerstitial f...

    Authors: Dantong Li, Jinglan Zhang, Xinyu Su, Yichen Yang, Jiayong Lai, Xiaoya Wei, Huamu Chen, Yaqing Liu, Haiyan Wang and Liangzhong Sun
    Citation: Molecular Medicine 2025 31:166
    Content type: Research Published on:

  32. Whole-brain radiotherapy (WBRT) is an important way to treat multiple metastases. Ultra-high dose rate (FLASH) can avoid neurotoxicity caused by conventional irradiation, it has attracted much attention. This ...

    Authors: Feifei Gao, Wei Cheng, Yanxi Ma, Boyi Yu, Xinle Lang, Xiaodong Jin, Jianxin Wang, Xianhong Liu, Cuixia Di, Hui Wang, Fei Ye, Ting Zhao, Weiqiang Chen and Qiang Li
    Citation: Molecular Medicine 2025 31:165
    Content type: Research Published on:

  33. Brain-derived neurotrophic factor (BDNF) expression is reduced in the brain of various central nervous system (CNS) disorders, but its relation to peripheral expression remains unclear. This study aimed to det...

    Authors: Janet Wang, William Schupp and Kazuko Sakata
    Citation: Molecular Medicine 2025 31:164
    Content type: Research Published on:

  34. Mitophagy, essential for cellular homeostasis, is involved in eliminating damaged mitochondria and is associated with cancer progression and chemoresistance. The specific impact of mitophagy on microsatellite ...

    Authors: Zhiyong Wang, Cheng Yu, Gengchen Xie, Kaixiong Tao, Zhijie Yin and Qing Lv
    Citation: Molecular Medicine 2025 31:163
    Content type: Research Published on:

  35. Placental angiogenesis is particularly important in the treatment of intrahepatic cholestasis of pregnancy (ICP). Although BACH1 has been implicated in angiogenesis associated with cardiovascular diseases, its...

    Authors: Shengpeng Li, Weiying Zhu, Zhixuan Xing, Dan Chen, Huimin Zhao, Yanli Zhang, Wenlong Zhang, Jiaojiao Sun, Yaxian Wu, Ling Ai and Qingfeng Pang
    Citation: Molecular Medicine 2025 31:162
    Content type: Research Published on:

  36. Osteoarthritis (OA) is an age-related degenerative disease that affects bones and joints. The hallmark pathogenesis of OA is associated with chondrocyte senescence. Surfactant protein D (SP-D) is a member of t...

    Authors: Huanyu Jiang, Yantao Zhang, Piyao Ji, Jianghua Ming, Yaming Li and Yan Zhou
    Citation: Molecular Medicine 2025 31:161
    Content type: Research Published on:

  37. Thymosin β10 (TMSB10) has emerged as a key player in the progression of prostate cancer, significantly influencing the tumor immune microenvironment. Pan-cancer analysis from The Cancer Genome Atlas (TCGA) rev...

    Authors: Haoran Xia, Jiaxin Ning, Xiaoxiao Guo, Hongchen Song, Xuanhao Li and Xuan Wang
    Citation: Molecular Medicine 2025 31:160
    Content type: Research Published on:

  38. Neonates, especially those born prematurely, are highly vulnerable to infection-induced mortality. Numerous observational and immunological studies in newborns have shown that live attenuated vaccines have ben...

    Authors: Jaimar C. Rincon, Dayuan Wang, Valerie E. Polcz, Evan L. Barrios, Marvin L. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Leilani Zeumer-Spataro, Feifei Xiao, Philip A. Efron, Lyle L. Moldawer, Guoshuai Cai and Shawn D. Larson
    Citation: Molecular Medicine 2025 31:159
    Content type: Research Published on:

  39. Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by the loss of motor neurons in the spinal cord. Our team has initiated clinical trials using adeno-associated virus serotype 9 (AAV9) ve...

    Authors: Wenhao Ma, Zhijie Wu, Tianyi Zhao, Yan Xia, Jing Qin, Xue Tian, Xin Li, Jun He, Yan Zhang, Lina Zhang, Li Li, Zheyue Dong, Zhichun Feng, Xiaoyan Dong, Wang Sheng and Xiaobing Wu
    Citation: Molecular Medicine 2025 31:158
    Content type: Research Published on:

  40. Whereas intestinal epithelial barrier dysfunction is implicated in inflammatory bowel disease (IBD), the underlying mechanisms remain elusive. Tumor necrosis factor α stimulated gene 6 (TSG-6) is a secretory p...

    Authors: Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang and Shi Wang
    Citation: Molecular Medicine 2025 31:157
    Content type: Research Published on:

  41. Authors: Wenyi Cai, Antong Wu, Zhongxiao Lin, Wei Cao, Janak L. Pathak, Richard T. Jaspers, Rui Li, Xin Li, Kaihan Zheng, Yufu Lin, Na Zhou, Xin Zhang, Yizhun Zhu and Qingbin Zhang
    Citation: Molecular Medicine 2025 31:156
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2025 31:128

  42. Endometriosis can lead to decreased endometrial receptivity, reduced rates of implantation, and diminished ovarian reserve. Currently, more than 50% of infertile women are found to suffer from endometriosis. H...

    Authors: Lu Liu, Lan Liu, Chenjing Yue, Shiyu Du, Jiayu Liu and Zhenhai Yu
    Citation: Molecular Medicine 2025 31:155
    Content type: Research Published on:

  43. The irreversible degeneration of dopamine neurons induced by α-synuclein (α-syn) aggregation in the substantia nigra is the central pathological feature of Parkinson's disease (PD). Neuroimaging and pathologic...

    Authors: Yan Chen, Xixi Luo, Yukun Yin, Elizabeth Rosalind Thomas, Kezhi Liu, Wenjun Wang and Xiang Li
    Citation: Molecular Medicine 2025 31:154
    Content type: Review Published on:

  44. The dysregulation of neuroinflammation triggered by imbalance of microglia M1/M2 polarization is a key pathogenic factor and closely associated with occurrence of depression. Formononetin (FMN), a natural non-...

    Authors: Shuaijun Peng, Pan Su, Liming Liu, Zibo Li, Yuan Liu, Lei Tian, Ming Bai, Erping Xu and Yucheng Li
    Citation: Molecular Medicine 2025 31:153
    Content type: Research Published on:

  45. Hepatocellular carcinoma (HCC) is the third major cause of cancer death worldwide, with more than a doubling of incidence over the past two decades in the United States. Yet, the survival rate remains less tha...

    Authors: Katrina Li, Brandon Mathew, Ethan Saldanha, Puja Ghosh, Adrian R. Krainer, Srinivasan Dasarathy, Hai Huang, Xiyan Xiang and Lopa Mishra
    Citation: Molecular Medicine 2025 31:152
    Content type: Review Published on:

  46. SARS-CoV- 2 continues to evolve, producing novel Omicron subvariants through recombinant lineages that acquire new mutations, undermining existing antiviral strategies. The viral fitness and adaptive potential...

    Authors: Sara Moreno-Jiménez, Gina Lopez-Cantillo, Jenny Andrea Arevalo-Romero, Ana María Perdomo-Arciniegas, Andrea Marisol Moreno-Gonzalez, Bellaneth Devia-Mejia, Bernardo Armando Camacho, Paulino Gómez-Puertas and Cesar A. Ramirez-Segura
    Citation: Molecular Medicine 2025 31:151
    Content type: Brief Report Published on:

  47. Chemotherapy sensitivity is an important factor that restricts the prognosis of breast cancer, and breast cancer stem cells (BCSCs) are the root cause of chemotherapy sensitivity. SNORA47, a member of the smal...

    Authors: Qilin Han, Ying Zhou, Zixian Dong, Weitao Wang, Menghan Wang, Mengyang Pang, Xinyue Song, Bo Chen and Ang Zheng
    Citation: Molecular Medicine 2025 31:150
    Content type: Research Published on:

  48. Mounting evidence shows that gut microbiota communities and the human immune system coexist and influence each other, and there are a number of reports of a correlation between specific changes in gut microbio...

    Authors: Lun He, Xin Li, Shan Jiang, Yanhua Ou, Shanshan Wang, Na Shi, Zhongshan Yang, Jia-li Yuan, Gregg Silverman and Haitao Niu
    Citation: Molecular Medicine 2025 31:149
    Content type: Review Published on:

  49. Intestinal ischemia–reperfusion (I/R) injury, which occurs in the ileum and not only leads to intestinal tissue damage, but also may trigger systemic inflammatory responses, is a prevalent pathological conditi...

    Authors: Cuifen Wang, Shangfei Luo, Yameng Yan, Jinze Li, Weipin Niu, Tianying Hong, Kai Hao, Xin Sun, Jiali Liu, Ran An and Jing Li
    Citation: Molecular Medicine 2025 31:147
    Content type: Research Published on:

  50. In the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is e...

    Authors: Wenjie Zhang, Min Xia, Jiahui Li, Gaohua Liu, Yan Sun, Xisha Chen and Jing Zhong
    Citation: Molecular Medicine 2025 31:146
    Content type: Review Published on:
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    Journal Impact Factor: 6.0
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    Source Normalized Impact per Paper (SNIP): 0.907
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Molecular Medicine

ISSN: 1528-3658