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  1. Sleep apnea syndrome (SAS) is associated with hypertension and vascular remodeling. Hypoxia-inducible factor-1α (HIF-1α) and the Hippo–YAP pathway are implicated in these processes, but their specific roles re...

    Authors: Shoude Zhang, Yuan Zhao, Zhanwei Dong, Mao Jin, Ying Lu, Mina Xu, Hong Pan, Guojin Zhou and Mang Xiao
    Citation: Molecular Medicine 2024 30:281
    Content type: Research article Published on:

  2. Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We ...

    Authors: David J. Gregory, Feifei Han, Peng Li, Marina A. Gritsenko, Jennifer Kyle, Frank E. Riley, Deborah Chavez, Vania Yotova, Renata H. M. Sindeaux, Mohamed B. F. Hawash, Fengyun Xu, Li-Yuan Hung, Douglas L. Hayden, Ronald G. Tompkins, Robert E. Lanford, Lester Kobzik…
    Citation: Molecular Medicine 2024 30:280
    Content type: Research Published on:

  3. Metabolic syndrome (MetS) is an indicator and diverse endocrine syndrome that combines different metabolic defects with clinical, physiological, biochemical, and metabolic factors. Obesity, visceral adiposity ...

    Authors: Md. Sharifull Islam, Ping Wei, Md Suzauddula, Ishatur Nime, Farahnaaz Feroz, Mrityunjoy Acharjee and Fan Pan
    Citation: Molecular Medicine 2024 30:279
    Content type: Review Published on:

  4. Nonalcoholic fatty liver disease (NAFLD) has developed as a leading public wellness challenge as a result of changes in dietary patterns. Unfortunately, there is still a lack of effective pharmacotherapy metho...

    Authors: Suhong Chen, Chuanjie Zhou, Jiahui Huang, Yunlong Qiao, Ning Wang, Yuzhen Huang, Bo Li, Wanfeng Xu, Xinglishang He, Kungen Wang, Yihui Zhi, Guiyuan Lv and Shuhua Shen
    Citation: Molecular Medicine 2024 30:278
    Content type: Research Published on:

  5. Diabetes often causes diabetic nephropathy (DN), a serious long-term complication. It is characterized by chronic proteinuria, hypertension, and kidney function decline, can progress to end-stage renal disease...

    Authors: ChangYan Li, Chen Geng, JiangMing Wang, Luyao Shi, JingYuan Ma, Zhang Liang and WenXing Fan
    Citation: Molecular Medicine 2024 30:277
    Content type: Research Published on:

  6. Recent studies have identified hearing loss (HL) as a primary risk factor for Alzheimer’s disease (AD) onset. However, the mechanisms linking HL to AD are not fully understood. This study explored the effects ...

    Authors: Yoo-Seung Ko, Young-Kyoung Ryu, Sujin Han, Hyung Joon Park, Munyoung Choi, Byeong C. Kim, Han-Seong Jeong, Sujeong Jang, Jihoon Jo, Sungsu Lee, Won-Seok Choi and Hyong-Ho Cho
    Citation: Molecular Medicine 2024 30:276
    Content type: Research Published on:

  7. Preeclampsia (PE) is a serious pregnancy complication associated with impaired trophoblast function. Integrin β3 (ITGB3) is a cell adhesion molecule that plays a role in cell movement. The objective of this st...

    Authors: Chunyan Li, Yanan Meng, Beibei Zhou, Yanrong Zhang, Qing Xia, Yu Huang, Li Meng, Chunjian Shan, Jiaai Xia, Xiangdi Zhang, Qiuhong Wang, Mingming Lv and Wei Long
    Citation: Molecular Medicine 2024 30:275
    Content type: Research article Published on:

  8. Small cell lung cancer (SCLC) is a highly fatal malignancy, the complex tumor microenvironment (TME) is a critical factor affecting SCLC progression. Cancer-associated fibroblasts (CAFs) are crucial components...

    Authors: Yuanhua Lu, Hui Li, Peiyan Zhao, Xinyue Wang, Wenjun Shao, Yan Liu, Lin Tian, Rui Zhong, Haifeng Liu and Ying Cheng
    Citation: Molecular Medicine 2024 30:274
    Content type: Research Published on:

  9. Acute myocardial infarction (AMI) remains a significant cause of global mortality, exacerbated by ischemia-reperfusion (IR) injury. Myocardial cell pyroptosis has emerged as a critical pathway influencing IR i...

    Authors: Yi Li, Xiang Wang, Xuyang Meng, Chenxi Xia, Chenguang Yang, Jun Wang, Jiefu Yang and Fang Wang
    Citation: Molecular Medicine 2024 30:273
    Content type: Research Published on:

  10. Doublecortin (DCX) is a microtubule-associated protein known to be a key regulator of neuronal migration and differentiation during brain development. However, the role of DCX, particularly in regulating the s...

    Authors: Iqra Nadeem, Zhou Han, Hong Xiaoliang, Seyram Yao Adzraku, Piniel Alphayo Kambey, Kouminin Kanwore, Mu Peipei, Adebayo Oluwafemi Adekunle, Joseph Adu-Amankwaah, Abiola Abdulrahman Ayanlaja, Yi Zheng, Gao Dianshuai, Xiaomei Liu and Yuanjian Song
    Citation: Molecular Medicine 2024 30:272
    Content type: Research Published on:

  11. Bipolar disorder (BD) is a severe, chronic mental illness that remains difficult to diagnose due to the lack of specific biomarkers, relying primarily on clinical assessments. Early diagnosis and treatment are...

    Authors: Alejandra Delgado-Sequera, Jose I. Pérez-Revuelta, Andres Caballero-García, MªCarmen Durán-Ruiz, Cristina Romero-Lopez-Alberca, Clara García-Mompó, Francisco González-Saiz, Manuel Rodríguez-Iglesias, Daniel Sanchez-Morillo, Patricia Robledo, Victor Perez, Esther Berrocoso and Maria Hidalgo-Figueroa
    Citation: Molecular Medicine 2024 30:271
    Content type: Research Published on:

  12. Rheumatoid arthritis (RA) and cardiovascular disease (CVD) are both the chronic inflammatory disease. To investigate the influence of secondary atherosclerosis on arthritis mice, we treated the ApoE−/− mice with ...

    Authors: Na Shi, Shan Jiang, Yue Zhao, Yang Zhang, Xinwang Duan, Guo-bao Hong, Zhongshan Yang, Yuanyuan Duan and Haitao Niu
    Citation: Molecular Medicine 2024 30:270
    Content type: Research Published on:

  13. ADAM19 (ADAM Metallopeptidase Domain 19) is known to be involved in extracellular matrix (ECM) remodeling, yet its specific function in systemic sclerosis (SSc) fibrosis remains unclear.

    Authors: Qiming Meng, Ding Bao, Sijia Liu, Jing Huang, Muyao Guo, Bingying Dai, Liqing Ding, Shasha Xie, Meng Meng, Chunliu Lv, Weijia He, Hui Luo and Honglin Zhu
    Citation: Molecular Medicine 2024 30:269
    Content type: Research Published on:

  14. Diabetes is a multi-factorial disorder and related complications constitute one of the principal causes of global mortality and disability. The role of ferroptosis in diabetes and its complications is intricat...

    Authors: Changqing Dong, Wuda Huoshen, Yunfeng Bai, Jiaona Liu, Bing Li, Yucan Guan and Ping Luo
    Citation: Molecular Medicine 2024 30:268
    Content type: Research Published on:

  16. Periprosthetic osteolysis and subsequent aseptic loosening are the leading causes of failure following total joint arthroplasty. Osteogenic impairment induced by wear particles is regarded as a crucial contrib...

    Authors: Xin Yu, Juan Jiang, Cheng Li, Yang Wang, Zhengrong Ren, Jianlun Hu, Tao Yuan, Yongjie Wu, Dongsheng Wang, Ziying Sun, Qi Wu, Bin Chen, Peng Fang, Hao Ding, Jia Meng, Hui Jiang…
    Citation: Molecular Medicine 2024 30:266
    Content type: Research Published on:

  17. Diabetic kidney disease (DKD), one of the most prevalent microvascular complications of diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in the deterioration ...

    Authors: Fengzhao Liu, Zhenyu Yang, Jixin Li, Tao Wu, Xiangyu Li, Lijuan Zhao, Wenru Wang, Wenfei Yu, Guangheng Zhang and Yunsheng Xu
    Citation: Molecular Medicine 2024 30:265
    Content type: Review Published on:

  18. Understanding the molecular mechanisms in immunosuppressive regulation is crucial for improving immunotherapeutic strategies. Macrophages, the major immune cells in tumor microenvironment (TME), play a dual ro...

    Authors: Wen Wang, Junsheng Li, Qiheng He, Chenglong Liu, Zhiyao Zheng, Bojian Zhang, Siqi Mou, Wei Sun and Jizong Zhao
    Citation: Molecular Medicine 2024 30:264
    Content type: Research Published on:

  20. Mast cells are implicated in the pathogenesis and severity of asthma in children and adults. The release of proinflammatory mediators and cytokines from activated mast cells (MC) is associated with Type 2 (T2)...

    Authors: Wun-Hao Cheng, Ting-Li Zhuang, Meng-Jung Lee, Chun-Liang Chou, Bing-Chang Chen, Han-Pin Kuo and Chih-Ming Weng
    Citation: Molecular Medicine 2024 30:262
    Content type: Research Published on:

  21. We have previously reported that the gap junction protein connexin 43 (Cx43) was upregulated in chronic renal disease in humans and rodents and plays a crucial role in the progression of experimental nephropat...

    Authors: Magali Genest, Satoshi Kinugasa, Elena Roger, Louis Boutin, Sandrine Placier, Stefanny Figueroa, Aude Dorison, Safia Hadjadj, Ines Baba, Emmanuel L. Gautier, Panagiotis Kavvadas, Christos Chatziantoniou and Christos E. Chadjichristos
    Citation: Molecular Medicine 2024 30:261
    Content type: Research article Published on:

  22. Osteosarcoma, the most prevalent primary bone malignancy in children and adolescents, exhibits high heterogeneity. The CGREF1 gene encodes a novel 301 amino acid classical secreted protein that contains the pr...

    Authors: Zicheng Wei, Kezhou Xia, Wenda Liu, Xinghan Huang, Zhun Wei and Weichun Guo
    Citation: Molecular Medicine 2024 30:260
    Content type: Research Published on:

  23. Pancreatic diseases pose considerable health challenges due to their complex etiology and limited therapeutic options. Mitochondrial uncoupling protein 2 (UCP2), highly expressed in pancreatic tissue, particip...

    Authors: Kunpeng Wang, Lilong Zhang, Beiying Deng, Kailiang Zhao, Chen Chen and Weixing Wang
    Citation: Molecular Medicine 2024 30:259
    Content type: Mini Review Published on:

  24. Recently, the incidence of pancreatic cancer (PC) has gradually increased. Research has shown that UTX mutants are critical in tumors. However, the underlying mechanisms remain incompletely understood. This st...

    Authors: Xiao-hua Shen, Shu-ping Xiong, Sheng-peng Wang, Shan Lu, Yi-ye Wan and Hui-qing Zhang
    Citation: Molecular Medicine 2024 30:258
    Content type: Research Published on:

  25. Gestational diabetes mellitus (GDM) has been associated with several fetal complications, such as macrosomia and fetal growth restriction (FGR). Infants from GDM associated FGR are at increased risk for adult-...

    Authors: Qin Zhang, Xi Yuan, Xiaojin Luan, Ting Lei, Yiran Li, Wei Chu, Qi Yao, Philip N. Baker, Hongbo Qi and Hui Li
    Citation: Molecular Medicine 2024 30:257
    Content type: Research Published on:

  26. The blood–brain barrier (BBB) is the most central component of the neurovascular unit (NVU) and is crucial for the maintenance of the internal environment of the central nervous system and the regulation of ho...

    Authors: Jia-Cheng Liu, Shuang-Yin Lei, Dian-Hui Zhang, Qian-Yan He, Ying-Ying Sun, Hong-Jing Zhu, Yang Qu, Sheng-Yu Zhou, Yi Yang, Chao Li and Zhen-Ni Guo
    Citation: Molecular Medicine 2024 30:256
    Content type: Review Published on:

  27. PIEZO1 has emerged as a mechanoreceptor linked with adipogenesis, adipose tissue (AT) inflammation and insulin resistance. We aimed to determine the impact of obesity and obesity-associated type 2 diabetes (T2...

    Authors: Victoria Catalán, Javier Gómez-Ambrosi, Beatriz Ramírez, Xabier Unamuno, Sara Becerril, Amaia Rodríguez, Jorge Baixauli, Gabriel Reina, Ana Sancho, Camilo Silva, Javier A. Cienfuegos and Gema Frühbeck
    Citation: Molecular Medicine 2024 30:255
    Content type: Research Published on:

  28. Recent data has shown a considerable advancement in understanding the role of lymphotoxin-β receptor (LTβR) in inflammation. However, the functions and underlying mechanisms of LTβR in acute kidney injury (AKI...

    Authors: Zufeng Wang, Yichun Cheng, Jiahe Fan, Ran Luo, Gang Xu and Shuwang Ge
    Citation: Molecular Medicine 2024 30:254
    Content type: Research Published on:

  29. Bronchopulmonary dysplasia (BPD), a chronic lung disease prevalent among premature infants, significantly impacts lifelong respiratory health. Macrophages, as key components of the innate immune system, play a...

    Authors: Bingrui Yu, Siyuan Jia, Yu Chen, Rong Guan, Shuyu Chen, Wanwen Tang, Tianping Bao and Zhaofang Tian
    Citation: Molecular Medicine 2024 30:253
    Content type: Research Published on:

  30. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, with the characteristics of high mortality and low 5-year survival rate. The potential role of BTF3 and PDCD2L in HCC remains unclear....

    Authors: Minyu Kong, Xiaoyi Shi, Jie Gao and Wenzhi Guo
    Citation: Molecular Medicine 2024 30:252
    Content type: Research article Published on:

  31. Primordial follicle activation is vital for the reproduction of women with advanced age and premature ovarian insufficiency (POI). But there is a lack of effective and safe therapeutic options to activate thei...

    Authors: Shuang Liu, Weiyong Wang, Huiyu Liu, Hongwei Wei, Yashuang Weng, Wenjun Zhou, Xiaodan Zhang, Sihui He, Ye Chen, Yahong Wang, Meijia Zhang and Xin Chen
    Citation: Molecular Medicine 2024 30:251
    Content type: Research article Published on:

  32. Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes (T1D), arising from relative insulin deficiency and leading to hyperglycemia, ketonemia, and metabolic acidosis. Early detection and tre...

    Authors: Paolo Spagnolo, David Tweddell, Enis Cela, Mark Daley, Cheril Clarson, C. Anthony Rupar, Saverio Stranges, Michael Bravo, Gediminas Cepinskas and Douglas D. Fraser
    Citation: Molecular Medicine 2024 30:250
    Content type: Research Published on:

  33. Hypertrophic cardiomyopathy (HCM) is one of the most common cardiovascular diseases with no effective treatment due to its complex pathogenesis. A novel cell death, disulfidptosis, has been extensively studied...

    Authors: Huimin Fan, Xin Tan, Shuai Xu, Yiyao Zeng, Hailong Zhang, Tong Shao, Runze Zhao, Peng Zhou, Xiaohong Bo, Jili Fan, Yangjun Fu, Xulong Ding and Yafeng Zhou
    Citation: Molecular Medicine 2024 30:249
    Content type: Research Published on:

  34. Bone remodeling is a critical process that maintains skeletal integrity, orchestrated by the balanced activities of osteoclasts, which resorb bone, and osteoblasts, which form bone. Osteoclastogenesis, the for...

    Authors: Sheunghun Lee, Hyerim Lee, You-Jee Jang, Kyubin Lee, Hye-Jung Kim, Jung Yeol Lee, Jin-Man Kim, Sunyou Park, Jin Sook Song, Ji Hoon Lee, Tae Kyung Hyun, Jae-Il Park, Sun-Ju Yi and Kyunghwan Kim
    Citation: Molecular Medicine 2024 30:248
    Content type: Research Published on:

  35. Atrial fibrillation (AF) has high mortality and morbidity rates. However, the intracellular molecular complexity of the atrial tissue of patients with AF has not been adequately assessed.

    Authors: Na An, Fan Yang, Guoxia Zhang, Yuchen Jiang, Haoqi Liu, Yonghong Gao, Yingjian Li, Peifeng Ji, Hongcai Shang and Yanwei Xing
    Citation: Molecular Medicine 2024 30:247
    Content type: Research Published on:

  36. Acetaminophen (APAP)-induced acute liver injury (AILI) is the most prevalent cause of acute liver failure and mitochondrial dysfunction plays a dominant role in the pathogenesis of AILI. Mitochondrial transcri...

    Authors: Sisi Chen, Yaling Cao, Zihao Fan, Ling Xu, Zhenzhen Pan, Yao Gao, Linlin Wei, Qiaoxin Wei, Yuan Tian, Xiangying Zhang, Mei Liu and Feng Ren
    Citation: Molecular Medicine 2024 30:246
    Content type: Research Published on:

  37. NLRP3 inflammasome immoderate activation results in the occurrence of various inflammatory diseases, but the clinic medications targeting NLRP3 inflammasome are still not available currently. The strategy of d...

    Authors: Zhilei Wang, Jingwen Liu, Yu Mou, Yuchen Li, Wenhao Liao, Menglin Yao, Ting Wang, Hongping Shen, Qin Sun and Jianyuan Tang
    Citation: Molecular Medicine 2024 30:245
    Content type: Research article Published on:

  40. Triolein, a symmetric triglyceride exhibiting anti-inflammatory and antioxidant properties, has demonstrated potential in mitigating cellular damage. However, its therapeutic efficacy in ischemic stroke (IS) a...

    Authors: Chaoqun Wang, Yuntao Li, Yonggang Zhang, Daniel Smerin, Lijuan Gu, Shuting Jiang and Xiaoxing Xiong
    Citation: Molecular Medicine 2024 30:242
    Content type: Research Published on:

  41. Extragonadal follicle-stimulating hormone receptor (FSHR) expression at low levels has been shown in several normal and tumor tissues, including myometrium and adipose tissue. FSH-FSHR signaling in the myometr...

    Authors: Ewelina Palak, Donata Ponikwicka-Tyszko, Kamila Pulawska-Moon, Maria Sztachelska, Gabriela Milewska, Beata Modzelewska, Tomasz Kleszczewski, Maria L. Koivukoski, Piotr Bernaczyk, Hady Razak Hady, Piotr GoÅ‚aszewski, Aleksandra N. Lupinska, Marek Kulikowski, Adam Lemancewicz, Ilpo T. Huhtaniemi, Slawomir Wolczynski…
    Citation: Molecular Medicine 2024 30:241
    Content type: Research Published on:

  42. Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved.

    Authors: Yuesong Yin, Hai Hu, Yian Yang and Song Wu
    Citation: Molecular Medicine 2024 30:240
    Content type: Research Published on:

  43. Evidence has shown that oxidative stress induced by high glucose microenvironment in placenta of gestational diabetes mellitus (GDM) is indispensable to the progression of this condition. Adipokine chemerin wa...

    Authors: Xuan Zhou, Yi Jiang, Zizhuo Wang, Lijie Wei, Huiting Zhang, Chenyun Fang, Shenglan Zhu, Yuanyuan Du, Rui Su, Weikun Li, Zhenzhen He, Liangnan Zhang, Weidong Tan, Mengzhou He, Jun Yu, Shaoshuai Wang…
    Citation: Molecular Medicine 2024 30:239
    Content type: Research Published on:

  44. The fibrogenic conversion of satellite cells contributes to the atrophy and fibrosis of skeletal muscle, playing a significant role in the pathogenesis of age-related sarcopenia. Melatonin, a hormone secreted ...

    Authors: Guo-Zheng Zhu, Kai Zhao, Hong-Zhou Li, Di-Zheng Wu, Yun-Biao Chen, Dong Han, Jia-Wen Gao, Xing-Yu Chen, Yong-Peng Yu, Zhi-Wei Huang, Chen Tu and Zhao-Ming Zhong
    Citation: Molecular Medicine 2024 30:238
    Content type: Research Published on:

  45. Rheumatoid arthritis (RA) is a common autoimmune disease that can lead to irreversible joint damage when it occurs, but its pathogenesis has not yet been elucidated. In this study, we explored the roles of mac...

    Authors: Guozhi Yan, Rongrong Song, Jieyu Zhang, Zhihao Li, Zhantao Lu, Zijian Liu, Xiaokang Zeng and Jie Yao
    Citation: Molecular Medicine 2024 30:237
    Content type: Research article Published on:

  46. Polycomb proteins are conventionally known as global repressors in cell fate determination. However, recent observations have shown their involvement in transcriptional activation, the mechanisms of which need...

    Authors: Yu Hong, Ranran Dai, Xinlan Li, He Xu and Chao Wei
    Citation: Molecular Medicine 2024 30:236
    Content type: Research Published on:

  47. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide and few drugs are available for its treatment. Lycorine has effective anti-inflammatory and lipid-low...

    Authors: Ziwen Wang, Mengpei Zhu, Qian Li, Jiali Cao, Qiangqiang Zhong, Ze Jin, Yumei Huang, Qing Lan, Ya Gao and Zhifan Xiong
    Citation: Molecular Medicine 2024 30:235
    Content type: Research Published on:

  48. Hypertension is a leading risk factor for disability and deaths worldwide. Evidence indicates that alpha-mangostin(α-MG) can reduce blood pressure and improve target organ damage. Nonetheless, its pharmacologi...

    Authors: Qi-Qi Xue, Chu-Hao Liu and Yan Li
    Citation: Molecular Medicine 2024 30:234
    Content type: Research Published on:

  49. Allergic conjunctivitis (AC) affects people’s daily life and work, especially the health of children. Although there are few relevant studies, Th17/Treg imbalance plays an important role in AC development. The...

    Authors: Yang Yang, Yuezhi Zhang, Jingfan Fu and Xiaolong Yin
    Citation: Molecular Medicine 2024 30:233
    Content type: Research Published on:

  50. Pancreatic cancer is known for its poor prognosis and resistance to conventional therapies, largely due to the presence of cancer stem cells (CSCs) and aggressive angiogenesis. Effectively targeting these CSCs...

    Authors: Lingyu Hu, Xiaoguang Wang, Zhengwei Song, Fei Chen and Bin Wu
    Citation: Molecular Medicine 2024 30:231
    Content type: Research Published on:
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    Journal Impact Factor: 6.0
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    Source Normalized Impact per Paper (SNIP): 0.907
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Molecular Medicine

ISSN: 1528-3658